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CLEP® Study Guide Printable PDF · 36 pages

CLEP Biology Study Guide

Everything the CLEP Biology exam tests, in one PDF you can print. Built from the College Board's official outline, heaviest topics first.

  • 186 key terms, each with an example
  • 40 practice questions with every answer explained
  • A 2-page cram sheet for the night before
  • 2-, 4- and 8-week study plans built from the exam weights
Not sure yet? Try 10 free questions

Last updated 2026 · exam details checked against the College Board's published exam information in 2026

Look inside the guide

Real pages from the 36-page PDF.

Page 1 of the CLEP Biology Study Guide: the cover
Page 1 The cover
Page 6 of the CLEP Biology Study Guide: the Chapter 1 opener
Page 6 The Chapter 1 opener
Page 11 of the CLEP Biology Study Guide: a chapter quiz
Page 11 A chapter quiz
Page 35 of the CLEP Biology Study Guide: the 2-page cram sheet
Page 35 The 2-page cram sheet

What you get for $5

One chapter for each official content area, in the order the exam weighs them.

  • 📘36pages, printable
  • 🧭3chapters, heaviest first
  • 🔑186terms with examples
  • ✍️40practice questions, answers explained
  • ⚠️9exam traps to avoid
  • 📄2page cram sheet

Try 10 free Biology questions

In the style of the real exam, from all 3 areas. About 10 minutes, with every answer explained and a score by area.

10 questions  
  1. Question 1 · Organismal Biology

    A ring of bark, including the layer just beneath it, is removed all the way around a young tree's trunk. The wood in the center is left intact. Over the following months, what is the most likely outcome?

    Show the answer

    Answer: A. The roots slowly starve because sugars made in the leaves can no longer travel down through the phloem. Phloem lies in the inner bark, so removing a ring cuts the sugar route to the roots, which eventually starve. The xylem in the central wood still carries water upward.

    The trap: Leaves wilting quickly is wrong because xylem, which carries water up, is in the intact wood and is not removed.

  2. Question 2 · Molecular and Cellular Biology

    A lake stays much cooler than the surrounding land through a hot afternoon. Which property of water best explains this?

    Show the answer

    Answer: E. Its high specific heat, because hydrogen bonds absorb heat before molecules speed up. Water's high specific heat means it takes a lot of heat to raise its temperature. Much of the heat goes into breaking hydrogen bonds before molecules move faster.

    The trap: Cohesion is a real property of water, but it explains surface tension and water movement in plants, not slow warming.

  3. Question 3 · Population Biology

    In a population at Hardy-Weinberg equilibrium, 16% of individuals show a recessive trait. What percentage of the population are heterozygous carriers?

    Show the answer

    Answer: D. 48%. q squared is 0.16, so q = 0.4 and p = 0.6. Carriers are 2pq = 2 x 0.6 x 0.4 = 0.48, or 48%.

    The trap: The 40% choice is q, the frequency of the recessive allele. The question asks for carriers, which is 2pq.

  4. Question 4 · Organismal Biology

    On a hot, dry, windy afternoon a plant's guard cells lose water and its stomata close. Which result follows directly?

    Show the answer

    Answer: C. Water loss falls, but carbon dioxide uptake also falls. Closed stomata reduce transpiration, but the same pores admit carbon dioxide, so photosynthesis slows. It is a trade-off between saving water and taking in CO2.

    The trap: Faster water movement in the xylem is wrong because closing stomata reduces the evaporation that drives upward pull.

  5. Question 5 · Molecular and Cellular Biology

    In a cell, the final product of a pathway accumulates, and the first enzyme of that pathway slows down. Which mechanism is this?

    Show the answer

    Answer: B. Feedback inhibition. The end product shuts off an earlier enzyme, so the cell stops making more than it needs. That is feedback inhibition.

    The trap: Denaturation would unfold every enzyme in the pathway, not slow just the first one. Feedback inhibition is a reversible slowdown by a normal cell molecule.

  6. Question 6 · Population Biology

    A field's producers capture 20,000 kJ of energy. If about 10% of the energy passes to each higher trophic level, how much reaches the tertiary consumers?

    Show the answer

    Answer: C. 20 kJ. Primary consumers get 2,000 kJ, secondary consumers 200 kJ and tertiary consumers 20 kJ. Each step keeps about one tenth.

    The trap: The 200 kJ choice is the amount reaching secondary consumers, one level too early.

  7. Question 7 · Organismal Biology

    A short-day plant normally flowers when the night lasts longer than about 10 hours. A grower gives a plant 14 hours of darkness but turns on a lamp for five minutes in the middle of the dark period. What is most likely?

    Show the answer

    Answer: D. The plant fails to flower, since the broken night acts as two short nights. Flowering depends on the length of uninterrupted darkness. A brief flash splits the long night into two short ones, so the plant does not flower.

    The trap: Flowering normally because there are still 14 hours of darkness is wrong because the total is irrelevant; the unbroken dark period is what the plant measures.

  8. Question 8 · Molecular and Cellular Biology

    A pancreatic cell makes a digestive enzyme that it exports. Which sequence follows the enzyme's path?

    Show the answer

    Answer: B. Rough ER, then Golgi apparatus, then secretory vesicle. Proteins for export are built on ribosomes attached to the rough ER, modified and sorted at the Golgi, and carried to the membrane in vesicles.

    The trap: Starting at the Golgi is tempting because it handles shipping, but the Golgi only receives proteins that ribosomes have already made.

  9. Question 9 · Population Biology

    After a severe storm, most sparrows with medium-length wings survived, while those with very short or very long wings mostly died. Which process does this show?

    Show the answer

    Answer: A. Stabilizing selection. Individuals near the average survived and both extremes were removed. That is stabilizing selection.

    The trap: Directional selection would favor one extreme, such as only the longest wings. Here both extremes were lost.

  10. Question 10 · Organismal Biology

    A seedling is laid on its side in the dark. Within a day, the stem tip curves upward. Which explanation fits?

    Show the answer

    Answer: E. Auxin collects on the lower side, so those cells elongate more. Gravitropism: auxin moves to the lower side of the stem, where it stimulates elongation, pushing the tip upward.

    The trap: Phototropism is wrong because the seedling is in the dark, so light cannot be directing the bend.

The CLEP Biology exam at a glance

The CLEP Biology exam is a 90-minute, computer-based test from the College Board with about 115 multiple-choice questions. A score of 50 on the 20–80 scale earns an ACE credit recommendation of 6 semester hours, though each college sets its own policy. The exam covers 3 content areas; the heaviest is Organismal Biology at 34%.

Questions
About 115multiple choice
Time
90 minabout 47 seconds a question
Passing score
50on a 20–80 scale
ACE credit
6semester hours
Exam fee
$97paid to College Board
Calculator
Nonot allowed

Source: official CLEP Biology exam page.

What the exam covers

3 areas, heaviest first. The guide's chapters follow this order.

  1. Organismal Biology34%
  2. Molecular and Cellular Biology33%
  3. Population Biology33%

How it works

  1. 1Buy once, $5Secure checkout. No subscription needed.
  2. 2Download the PDFFrom your TransferCredit.org account, right away and any time later.
  3. 3Study the heaviest areas firstFollow the 2-, 4- or 8-week plan, then read the cram sheet the night before.

Questions students ask

What's in the full CLEP Biology study guide?
36 pages: 3 chapters, one per official content area, heaviest first. 186 terms, each with a plain-English definition and an example, 13 key people, common traps and memory tricks, 40 practice questions with an answer key that explains every answer, question tactics, 2-, 4- and 8-week study plans and a 2-page cram sheet.
How much is the full CLEP Biology study guide?
The full 36-page PDF is $5, a one-time payment. The 10 practice questions on this page are free, with no account.
What does the $29 plan include?
$29 a month gives you all 28 CLEP subjects: every CLEP study guide plus the full prep course for each subject, and you can cancel anytime. If you only need this exam, the guide on its own is a one-time $5.
How do I get the full guide?
Choose Buy this guide ($5) and check out. Then sign in to your TransferCredit.org account, then open the course and its Download Your Study Guide lesson. The PDF is yours to keep, and you can download it again from your account at any time.
Can I print the guide or use it on my phone?
Yes. It's a PDF, so it opens on phones, tablets and computers, and printing is allowed. Its tick boxes and answer bubbles work in PDF readers that support forms. Copying and editing are turned off.
Is this an official CLEP study guide?
No. CLEP® is a registered trademark of the College Board, which was not involved in producing this guide and does not endorse it. TransferCredit.org is independent. We built the guide from the official exam outline, and the exam details were checked against the College Board's published exam information in 2026.
Why is this study guide better than a generic review?
It follows the official outline area by area and spends the most pages on what the exam weighs most. Every term comes with an example, each chapter names the traps the exam sets, and the answer key explains why the most tempting wrong answer is wrong, not just which answer is right. It ends with a 2-page cram sheet for the night before.
What is the CLEP Biology exam?
The CLEP Biology exam is a 90-minute, computer-based test from the College Board with about 115 multiple-choice questions. A score of 50 on the 20–80 scale earns an ACE credit recommendation of 6 semester hours, though each college sets its own policy. The exam covers 3 content areas; the heaviest is Organismal Biology at 34%.
More questions about the CLEP Biology exam (18)
How many questions are on the CLEP Biology exam, and how long is it?
About 115 multiple-choice questions in 90 minutes. Some of the approximately 115 questions are pretest questions that will not be scored.
What is the passing score for CLEP Biology?
The passing score is 50 on a 20–80 scale. At 50 or above, the American Council on Education (ACE) recommends 6 semester hours. Each college sets its own passing score and credit award, so check your school's policy before you book.
How much does the CLEP Biology exam cost?
The exam fee is $97, paid to the College Board. Test centers may add their own administration fee. Eligible U.S. military service members can usually test for free through DANTES.
How many college credits is CLEP Biology worth?
ACE recommends 6 semester hours for a passing score of 50. Your college decides how many credits it awards and which course they replace. Check your college's policy.
Can I use a calculator on the CLEP Biology exam?
No. This exam doesn't allow a calculator.
Is there a penalty for guessing on CLEP Biology?
No. Your score counts only correct answers, so a wrong answer costs nothing. Never leave a question blank: rule out what you can and pick your best guess.
What topics are on the CLEP Biology exam?
3 content areas, from the official outline: Organismal Biology (34%); Molecular and Cellular Biology (33%); Population Biology (33%).
Which CLEP Biology topics should I study first?
Start with Organismal Biology (34%), the largest of the exam's 3 areas, then Molecular and Cellular Biology (33%) and Population Biology (33%). The guide's chapters run in that order, heaviest first.
Is the CLEP Biology exam hard?
It depends on what you already know. The exam has only 3 content areas, so each one carries real weight: Organismal Biology (34%), Molecular and Cellular Biology (33%) and Population Biology (33%). Take the free diagnostic above to see where you stand in about 10 minutes.
What kinds of questions are on the CLEP Biology exam?
The guide sorts them into 5 types: “Recall and identify”, “Experiment and conclusion”, “Predict the effect”, “Apply a rule or calculate” and “Compare and contrast”. Every question has 5 answer choices. Try the 10 free questions above to see the style.
How long should I study for CLEP Biology?
Use the diagnostic to decide. If you already know most areas, two weeks of daily review is often enough; if the subject is new to you, plan on eight. The full guide has 2-, 4- and 8-week plans built from the exam weights.
How should I pace myself on the CLEP Biology exam?
On average you have about 47 seconds per question (90 minutes for 115 questions). Be past question 38 a third of the way through and past question 77 two-thirds through. If a question takes more than a minute, pick your best guess, mark it and come back.
What happens if I don't pass CLEP Biology?
You can retake a CLEP exam after three months. Use the wait to work through the areas the score report and the diagnostic show you missed.
Do colleges accept CLEP Biology for credit?
CLEP exams are accepted at more than 2,900 U.S. colleges and universities, but each school decides which exams it accepts, the score it requires and the credit it gives. Look up your college's CLEP policy before you book.
How is the guide different from the CLEP Biology course?
The guide is a 36-page PDF for review and self-testing. The CLEP Biology course is a full online course with lessons, quizzes and a practice exam, for $19 with lifetime access. Many students use the guide first, then take the course for the areas the diagnostic flags.
How up to date is this CLEP Biology guide?
Last updated 2026. The exam details were checked against the College Board's published exam information in 2026. Exams change, so confirm the details on the official exam page before you register.
What should I do the night before the exam?
Read the cram sheet once, slowly. Check your test time, the location or remote-proctoring setup, and the ID you need. Then sleep: a rested brain recalls more than a crammed one. In the morning, skim the memory tricks and common traps, then stop studying.
Does CLEP Biology include a lab?
No. There's no lab component, though some questions ask you to interpret experiments and data. Some colleges require a separate lab to count the credit as a lab science.

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CLEP® is a registered trademark of the College Board, which was not involved in producing this guide and does not endorse it. TransferCredit.org is independent and not affiliated with the College Board. © 2026 UPI Globale Edu Inc.